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KMID : 0043319990220060575
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Archives of Pharmacal Research
1999 Volume.22 No. 6 p.575 ~ p.578
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Synthesis of Sesquiterpene Derivitives as Potential Antitumor Agents; Elemance Derivatives
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Choi Bo-Gil
Kwak Eun-Yee
Chung Byung-Ho
Cho Won-Jea
Cheon Seung-Hoon
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Abstract
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Derivatives of elema-1,3-diene were synthesized in several steps as polar analogs of -elemene, antitumor agent under clinical phase. The lactone ring of compound 1 was opened by LiAlH4 to give diol 2 which was selectively protected by TBDPSCI. After acetylation of the secondary alcohol, the acetylated product was ozonolyzed and reduced to give elemene derivative 4 which was converted to diolefin 8 via selenides subsequent deprotection by tetrabutylammonium fluoride gave two compounds 9, 10.
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KEYWORD
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Elema-1, 3-diene, Antitumor agent
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